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pentobarbital will decrease the level or impact of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.pentobarbital will lessen the extent or result of larotrectinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital boosts toxicity of methoxyflurane by raising metabolism. C